Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	St3gal2tm2Jxm
Name:	ST3 beta-galactoside alpha-2,3-sialyltransferase 2; targeted mutation 2, Jamey Marth
MGI ID:	MGI:3699715
Synonyms:	ST3Gal-IIF
Gene:	St3gal2  Location: Chr8:111646554-111699112 bp, + strand  Genetic Position: Chr8, 57.81 cM
Alliance:	St3gal2tm2Jxm page

Germline Transmission:	Earliest citation of germline transmission: J:80119
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette downstream of the exon containing the large sialyl motif and a loxP site upstream of the exon. Correctly targeted ES cells were transfected with a Cre expression plasmid to excise the neo fragment, leaving the floxed exon. (J:80119)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any St3gal2 Mutation:	37 strains or lines available

Original:	J:80119 Ellies LG, et al., Sialyltransferase specificity in selectin ligand formation. Blood. 2002 Nov 15;100(10):3618-25
All:	2 reference(s)