Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abca2tm1Kdt
Name:	ATP-binding cassette, sub-family A member 2; targeted mutation 1, Kenneth D Tew
MGI ID:	MGI:3697467
Synonyms:	Abca2-
Gene:	Abca2  Location: Chr2:25318715-25338552 bp, + strand  Genetic Position: Chr2, 17.25 cM, cytoband A2-B
Alliance:	Abca2tm1Kdt page

Germline Transmission:	Earliest citation of germline transmission: J:117673
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 23-30 were replaced with a neomycin resistance cassette. This sequence encoded the first nucleotide binding domain. (J:117673)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca2 Mutation:	75 strains or lines available

Original:	J:117673 Mack JT, et al., 'Skittish' Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan;27(1):44-53
All:	3 reference(s)