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Apba2tm1Tsuz
Targeted Allele Detail
Summary
Symbol: Apba2tm1Tsuz
Name: amyloid beta precursor protein binding family A member 2; targeted mutation 1, Toshiharu Suzuki
MGI ID: MGI:3697454
Synonyms: X11L-KO
Gene: Apba2  Location: Chr7:64151454-64403626 bp, + strand  Genetic Position: Chr7, 34.65 cM
Alliance: Apba2tm1Tsuz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117646
Parent Cell Line:  MS12 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced sequence containing the ATG by homologous recombination and was subsequently removed via cremediated recombination. Western blot failed to detect protein in mutant mice. (J:117646)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apba2 Mutation:  45 strains or lines available
References
Original:  J:117646 Sano Y, et al., Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem. 2006 Dec 8;281(49):37853-60
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory