Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Apoc1tm2Lmh
Name:	apolipoprotein C-I; targeted mutation 2, Louis M Havekes
MGI ID:	MGI:3697323
Gene:	Apoc1  Location: Chr7:19423405-19426584 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance:	Apoc1tm2Lmh page

Germline Transmission:	Earliest citation of germline transmission: J:28261
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A replacement vector was used to disrupt exons 1 and 2 of the Apoc1 gene by replacing them with a 2 kb hygromycin B-resistance gene. The vector was transfected into a heterozygous Apoe-deficient E14 ES cell line. Mice produced from the doubly targeted ES cells disrupted alleles of both Apoe and Apoc1. (J:22858, J:28261)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoc1 Mutation:	10 strains or lines available

Original:	J:28261 van Ree JH, et al., Inactivation of Apoe and Apoc1 by two consecutive rounds of gene targeting: effects on mRNA expression levels of gene cluster members. Hum Mol Genet. 1995 Aug;4(8):1403-9
All:	3 reference(s)