Ercc2tm2Jmch
Targeted Allele Detail
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Symbol: |
Ercc2tm2Jmch |
Name: |
excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, James R Mitchell |
MGI ID: |
MGI:3696121 |
Synonyms: |
XpdG602D, Xpd+XPCS |
Gene: |
Ercc2 Location: Chr7:19115942-19129619 bp, + strand Genetic Position: Chr7, 9.62 cM
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Alliance: |
Ercc2tm2Jmch page
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Cutaneous phenotypes of Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh and Ercc2tm2(ERCC2)Jhjh/Ercc2tm2Jmch mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:116054
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A G602D point mutation was inserted with a neo in the 3' UTR. The neo was not removed from this allele. RT-PCR detected about a 5-fold reduction in expression compared to the wild-type allele.
(J:116054)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ercc2 Mutation: |
23 strains or lines available
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Original: |
J:116054 Andressoo JO, et al., Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles. PLoS Biol. 2006 Oct;4(10):e322 |
All: |
1 reference(s) |
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