Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Napepldtm1Crv
Name:	N-acyl phosphatidylethanolamine phospholipase D; targeted mutation 1, Benjamin F Cravatt
MGI ID:	MGI:3695401
Synonyms:	NAPE-PLD-
Gene:	Napepld  Location: Chr5:21867899-21906394 bp, - strand  Genetic Position: Chr5, 9.97 cM
Alliance:	Napepldtm1Crv page

Germline Transmission:	Earliest citation of germline transmission: J:108301
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced with a neomycin resistance gene by homologous recombination. This exon encodes the majority of the protein sequence including the conserved HXHXDH catalytic residues. Absence of transcript and protein was confirmed in RT-PCR and Western blot analyses. (J:108301)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Napepld Mutation:	24 strains or lines available

Original:	J:108301 Leung D, et al., Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 2006 Apr 18;45(15):4720-6
All:	7 reference(s)