Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abcc3tm1Kruh
Name:	ATP-binding cassette, sub-family C member 3; targeted mutation 1, Gary D Kruh
MGI ID:	MGI:3689906
Synonyms:	Mrp3-
Gene:	Abcc3  Location: Chr11:94234121-94283823 bp, - strand  Genetic Position: Chr11, 58.9 cM
Alliance:	Abcc3tm1Kruh page

Germline Transmission:	Earliest citation of germline transmission: J:114229
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 6-8, including nucleotides 613-996, were replaced by a neo cassette. The substitution resulted in a frame shift. Western blot failed to detect wild-type protein in mutant mice. (J:114229)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc3 Mutation:	70 strains or lines available

Original:	J:114229 Belinsky MG, et al., Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005 Jul;68(1):160-8
All:	3 reference(s)