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Tg(KRT14-HGF)43Takk
Transgene Detail
Summary
Symbol: Tg(KRT14-HGF)43Takk
Name: transgene insertion 43, Takahiro Kusinada
MGI ID: MGI:3687336
Synonyms: HGFTg43, K14-HGF
Transgene: Tg(KRT14-HGF)43Takk  Location: unknown  
Alliance: Tg(KRT14-HGF)43Takk page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT14-HGF)43Takk expresses 1 gene
 
Mutation details: A full-length cDNA encoding human hepatocyte growth factor was inserted into an epidermis-directed expression cassette containing 2500 bp of 5' flanking plus untranslated-region DNA from the human keratin 14 gene, a rabbit beta-globin intron, and approximately 7 kb of 3' untranslated-region plus flanking sequence from the human keratin gene. Immunohistologic analysis demonstrates expression in the epidermis. (J:84399)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Three stably-expressing transgenic lines were derived and designated by the authors HGFTg1, HGFTg43 and HGFTg75. Skin pigmentation of line 1 is light, of line 43 moderate and of line 75 dark. Most analyses were performed on HGTf43.
References
Original:  J:84399 Kunisada T, et al., Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis. Mech Dev. 2000 Jun;94(1-2):67-78
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory