Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ace2tm1Cof
Name:	angiotensin converting enzyme 2; targeted mutation 1, Thomas M Coffman
MGI ID:	MGI:3665270
Gene:	Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance:	Ace2tm1Cof page

Germline Transmission:	Earliest citation of germline transmission: J:113108
Parent Cell Line:	MPI-12D (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced an exon containing sequences encoding the zinc-binding motif HEMGH. Northern blot analysis of RNA derived from kidney of mutant mice revealed that no detectable transcript is expressed from this allele. (J:113108)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:	54 strains or lines available

Original:	J:113108 Gurley SB, et al., Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug;116(8):2218-25
All:	33 reference(s)