Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncr1tm1Oman
Name:	natural cytotoxicity triggering receptor 1; targeted mutation 1, Ofer Mandelboim
MGI ID:	MGI:3664443
Synonyms:	Ncr1gfp
Gene:	Ncr1  Location: Chr7:4340723-4348163 bp, + strand  Genetic Position: Chr7, 2.5 cM
Alliance:	Ncr1tm1Oman page

Germline Transmission:	Earliest citation of germline transmission: J:112394
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 5-7 with an IRES-GFP-PGK-neo. The neo was removed via cre-mediated recombination. Absence of endogenous transcript was confirmed by RT-PCR. Fluorescence is more intense after excision by Tg(Prm-cre)58Og (129/Sv background) or by Tg(Sp3-cre)93Knw (C57BL/6 background). When allele is made congenic on 129 or C57BL/6 background, immune system phenotype is not altered by removal of PGK-neo or by background. (J:112394)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:	39 strains or lines available

Original:	J:112394 Gazit R, et al., Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 2006 May;7(5):517-23
All:	54 reference(s)