Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Adam21tm1Dgen
Name:	a disintegrin and metallopeptidase domain 21; targeted mutation 1, Deltagen
MGI ID:	MGI:3663320
Gene:	Adam21  Location: Chr12:81605358-81615248 bp, - strand  Genetic Position: Chr12, 37.79 cM
Alliance:	Adam21tm1Dgen page

Mutant Cell Line:	7990
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details:  A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts were detected in most tissues tested but not in heart, thymus, bone marrow, and urinary bladder. LacZ expression was detected in kidney and testis tissues. No LacZ expression was detected in nervous, cardiovascular, hematopoietic tissue, the respiratory system, liver, pancreas, urinary bladder, thyroid, pituitary, adrenal, prostate glands, skeletal muscle, skin, ovary, uterus, or cervix. (J:101679)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

31 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam21 Mutation:	37 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	1 reference(s)