Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Ins2-Fas*I246N)1Ach
Name:	transgene insertion 1, Alexander V Chervonsky
MGI ID:	MGI:3662920
Synonyms:	RIP-Fascg, RIP-Fascg Tg-Hi, RIP-Fas-lprcg, Tg(Ins2-Tnfrsf6lpr-cg)
Transgene:	Tg(Ins2-Fas*I246N)1Ach  Location: unknown
Alliance:	Tg(Ins2-Fas*I246N)1Ach page

Strain of Origin:

NOD/ShiLt

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Ins2-Fas*I246N)1Ach expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note rat Fas (246097) Fas  (MGI:95484)   Tg(Ins2-Fas*I246N)1Ach expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Ins2 (24506) Ins2  (MGI:96573)   Mutation details: Fas cDNA with a single nucleotide change leading to a I246N change in protein sequence, which codes for Fascg was subcloned into the rat insulin 2 promoter and injected into NOD/Lt oocytes to produce transgenic mice. (J:81416) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:81416 Savinov AY, et al., Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):628-32
All:	1 reference(s)