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Mymx Gene Detail
Summary
  • Symbol
    Mymx
  • Name
    myomixer, myoblast fusion factor
  • Synonyms
    minion, myomerger
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649059
    NCBI Gene: 653016
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45911897-45913028 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649059
 protein coding gene Chr17:45911887-45913122 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023795
 protein coding gene Chr17:46621573-46622708 (-)
A/J MGP_AJ_G0023753
 protein coding gene Chr17:45507845-45508980 (-)
AKR/J MGP_AKRJ_G0023724
 protein coding gene Chr17:45821814-45822949 (-)
BALB/cJ MGP_BALBcJ_G0023757
 protein coding gene Chr17:45395859-45396994 (-)
C3H/HeJ MGP_C3HHeJ_G0023521
 protein coding gene Chr17:46532883-46534018 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024200
 protein coding gene Chr17:48634336-48635471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021650
 protein coding gene Chr17:42302752-42303859 (-)
CAST/EiJ MGP_CASTEiJ_G0023002
 protein coding gene Chr17:46636909-46638045 (-)
CBA/J MGP_CBAJ_G0023497
 protein coding gene Chr17:50364656-50365791 (-)
DBA/2J MGP_DBA2J_G0023623
 protein coding gene Chr17:44300342-44301477 (-)
FVB/NJ MGP_FVBNJ_G0023590
 protein coding gene Chr17:43874948-43876083 (-)
LP/J MGP_LPJ_G0023704
 protein coding gene Chr17:47267474-47268609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023619
 protein coding gene Chr17:49931222-49932357 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024245
 protein coding gene Chr17:46185378-46186513 (-)
PWK/PhJ MGP_PWKPhJ_G0022747
 protein coding gene Chr17:43605789-43606934 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022562
 protein coding gene Chr17:43047986-43049128 (-)
WSB/EiJ MGP_WSBEiJ_G0023067
 protein coding gene Chr17:46702584-46703719 (-)



Homology
more
  • Human Ortholog
    MYMX, myomixer, myoblast fusion factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYMX, myomixer, myoblast fusion factor
  • Synonyms
    CFZS2, hMINION, MINION
  • Links
    NCBI Gene ID: 101929726
    neXtProt AC: NX_A0A1B0GTQ4
    UniProt: A0A1B0GTQ4

  • Chr Location
    chr6:44192721-44218234 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYMX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality with cyanosis, primary atelectasis and skeletal muscle defects associated with failure of myoblast fusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    36
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079471 Ensembl Gene Model | MGI Sequence Detail 1132 C57BL/6J ±  kb
    transcript ENSMUST00000169137 Ensembl | MGI Sequence Detail 616 Not Applicable  
    polypeptide ENSMUSP00000126690 Ensembl | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:340833 Cai S, et al., KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer. Cell Death Dis. 2023 Sep 18;14(9):612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory