Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Del(9Apoa1-Apoa4)1Hmez
Name:	deletion, Chr 9, Hafid Mezdour 1
MGI ID:	MGI:3628802
Synonyms:	Apoa1/Apoc3/Apoa4tm1Hmez, Apoa1/c3/a4-
Gene:	Del(9Apoa1-Apoa4)1Hmez  Location: unknown  Genetic Position: Chr9, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:109005
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion, Intragenic deletion   Del(9Apoa1-Apoa4)1Hmez involves 3 genes/genome features (Apoa1, Apoc3, Apoa4) View all   Mutation details: A neomycin resistance gene replaced the coding sequences of apolipoprotein A-I, apolipoprotein C-III and the first two exons of apolipoprotein A-IV. Northern blot of mutant liver and intestine demonstrated successful ablation of expression of all three genes. Western blot confirmed absence of protein of each gene. (J:109005)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(9Apoa1-Apoa4)1Hmez Mutation:	0 strains or lines available

Original:	J:109005 Mezdour H, et al., Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency. J Lipid Res. 2006 May;47(5):912-20
All:	1 reference(s)