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Gene Expression Data
Assay Details
Assay
Reference: J:106710 Takemoto M, et al., Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3625987
Gene symbol: Nphs1
Gene name: nephrosis 1, nephrin
Antibody: anti-mouse Nphs1
Detection system: Secondary antibody
Results
Specimen 5A +/+: embryonic day 18.5 (more )
Note: Double labeled: red - Nphs1; green - Pdgfrb (assay MGI:3625988).
Structure Level Pattern Image Note
TS26: visceral epithelium of capillary loop renal corpuscle Present Regionally restricted 5A Nphs1/Pdgfrb +/+ Expression is in podocytes.
Specimen 5A -/-: embryonic day 18.5; Foxc2tm1Miu/Foxc2tm1Miu (more )
Note: Double labeled: red - Nphs1; green - Pdgfrb (assay MGI:3625988).
Structure Level Pattern Image Note
TS26: visceral epithelium of capillary loop renal corpuscle Present Regionally restricted 5A Nphs1/Pdgfrb -/- Expression is in podocytes but the distribution is abnormal in this mutant.
Specimen 8B +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8B Nphs1 +/+
Specimen 8B -/-: embryonic day 18.5; Foxc2tm1Miu/Foxc2tm1Miu (more )
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8B Npsh1 -/- Expression in this mutant is the same as in wild-type embryos.
Specimen 8C +/+ Lama1: embryonic day 18.5 (more )
Note: Double labeled: green - Nphs1; red - Lama1 (assay MGI:3626107).
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8C Nphs1/Lama1 +/+
Specimen 8C -/- Lama1: embryonic day 18.5; Foxc2tm1Miu/Foxc2tm1Miu (more )
Note: Double labeled: green - Nphs1; red - Lama1 (assay MGI:3626107).
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8C Nphs1/Lama1 -/- Expression in this mutant is the same as in wild-type embryos.
Specimen 8C +/+ Lama2: embryonic day 18.5 (more )
Note: Double labeled: green - Nphs1; red - Lama2 (assay MGI:3626113).
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8C Nphs1/Lama2 +/+
Specimen 8C -/- Lama2: embryonic day 18.5; Foxc2tm1Miu/Foxc2tm1Miu (more )
Note: Double labeled: green - Nphs1; red - Lama2 (assay MGI:3626113).
Structure Level Pattern Image Note
TS26: glomerular tuft Present 8C Nphs1/Lama2 -/- Expression in this mutant is the same as in wild-type embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory