Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ddotm1Snyd
Name:	D-aspartate oxidase; targeted mutation 1, Solomon H Snyder
MGI ID:	MGI:3625623
Synonyms:	Ddo-
Gene:	Ddo  Location: Chr10:40506007-40557843 bp, + strand  Genetic Position: Chr10, 22.0 cM, cytoband B1
Alliance:	Ddotm1Snyd page

Germline Transmission:	Earliest citation of germline transmission: J:106267
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a neomycin resistance cassette by homologous recombination. The targeting event introduced a frame shift. Northern blot failed to detect transcript in mutant liver and kidney. Western blot confirmed absence of protein, as well. (J:106267)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddo Mutation:	14 strains or lines available

Original:	J:106267 Huang AS, et al., D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 8;26(10):2814-9
All:	3 reference(s)