Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Igkctm1Schz
Name:	immunoglobulin kappa constant; targeted mutation 1, Pierre Sanchez
MGI ID:	MGI:3624131
Synonyms:	Ckappa-
Gene:	Igkc  Location: Chr6:70703419-70703738 bp, + strand  Genetic Position: Chr6, 32.04 cM, cytoband C
Alliance:	Igkctm1Schz page

Germline Transmission:	Earliest citation of germline transmission: J:108003
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into the HpaI site of the constant kappa segment. Mutant mice did not express the kappa light chain in B cells. (J:108003)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igkc Mutation:	9 strains or lines available

Original:	J:108003 Sanchez P, et al., Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment. Int Immunol. 1994 May;6(5):711-9
All:	5 reference(s)