Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptgs2tm1Hahe
Name:	prostaglandin-endoperoxide synthase 2; targeted mutation 1, Harvey R Herschman
MGI ID:	MGI:3623499
Synonyms:	Cox-2flox, Ptgs2tm1Hrh
Gene:	Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Alliance:	Ptgs2tm1Hahe page

Germline Transmission:	Earliest citation of germline transmission: J:107615
Parent Cell Line:	LW1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to flank exons 4 and 5 with loxP sites. Deletion of these exons would cause a frame shift, resulting in a stop codon after eight missense amino acids in exon 6. (J:107615)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

List all tumor models in MMHCdb carrying Ptgs2tm1Hahe

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:107615 Ishikawa TO, et al., Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene. Genesis. 2006 Mar;44(3):143-9
All:	31 reference(s)