Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdkn1btm2Mlf
Name:	cyclin dependent kinase inhibitor 1B; targeted mutation 2, Matthew L Fero
MGI ID:	MGI:3623439
Synonyms:	p27L+, p27loxP
Gene:	Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Alliance:	Cdkn1btm2Mlf page

Germline Transmission:	Earliest citation of germline transmission: J:107588
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted to flank the locus. An FRT-flanked neo included in the vector was subsequently removed via flp mediated recombination. Protein was detected in mutants, but in moderately decreased amounts. (J:107588)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:	25 strains or lines available

Original:	J:107588 Chien WM, et al., Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4122-7
All:	10 reference(s)