Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Jag1tm1Jlew
Name:	jagged 1; targeted mutation 1, Julian Lewis
MGI ID:	MGI:3623344
Synonyms:	Jag1flox
Gene:	Jag1  Location: Chr2:136923371-136958440 bp, - strand
Alliance:	Jag1tm1Jlew page

Germline Transmission:	Earliest citation of germline transmission: J:107414
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted to flank exons encoding the DSL (Delta-Serrate-Lag2) domain required for binding to Notch. Expression of cre recombinase is expected to knock out gene function by removing exons 4 and 5 (the DSL encoding exons) and causing a frame shift that generates a stop codon after the start of exon 6. (J:107414)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:	76 strains or lines available

Original:	J:107414 Brooker R, et al., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 2006 Apr;133(7):1277-86
All:	30 reference(s)