Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kmt2btm1.1Afst
Name:	lysine (K)-specific methyltransferase 2B; targeted mutation 1.1, A Francis Stewart
MGI ID:	MGI:3623310
Synonyms:	Mll2 F, Mll2FC
Gene:	Kmt2b  Location: Chr7:30268283-30288151 bp, - strand  Genetic Position: Chr7, 18.63 cM, cytoband A3
Alliance:	Kmt2btm1.1Afst page

Germline Transmission:	Earliest citation of germline transmission: J:107403
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked sA-IRES lacZ-neo pA cassette was removed from intron 1 of Mll2tm1Afst via flp recombination and wild-type function was restored. (J:107403)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2b Mutation:	63 strains or lines available

Original:	J:107403 Glaser S, et al., Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006 Apr;133(8):1423-32
All:	11 reference(s)