Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cln3tm1Mkat
Name:	CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Martin L Katz
MGI ID:	MGI:3623134
Gene:	Cln3  Location: Chr7:126170571-126184991 bp, - strand  Genetic Position: Chr7, 69.16 cM
Alliance:	Cln3tm1Mkat page

Germline Transmission:	Earliest citation of germline transmission: J:57155
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced most of exon 7 and all of exon 8. No complete transcript was detected in mutants, however, two smaller mRNA transcripts putatively resulting from alternative splicing around the neo were detected. (J:57155)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cln3 Mutation:	38 strains or lines available

Original:	J:57155 Katz ML, et al., A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease). J Neurosci Res. 1999 Aug 15;57(4):551-6
All:	2 reference(s)