Adam19tm1Asf
Targeted Allele Detail
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Symbol: |
Adam19tm1Asf |
Name: |
ADAM metallopeptidase domain 19; targeted mutation 1, Atsuko Schara-Fujisawa |
MGI ID: |
MGI:3620562 |
Gene: |
Adam19 Location: Chr11:45946819-46038170 bp, + strand Genetic Position: Chr11, 27.54 cM, cytoband A5-B1.1
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Alliance: |
Adam19tm1Asf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:106261
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A PGK-neo replaced exons 10-12. Exon 11 contains the active site of the metalloprotease domain. The construct generated a frame shift, thereby allowing mutants to express only an N-terminal truncated protein. RT-PCR failed to detect wild-type transcript in mutants. An alternatively spliced isoform lacking the metalloprotease and disintegrin domains also failed to be detected.
(J:106261)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adam19 Mutation: |
77 strains or lines available
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Original: |
J:106261 Kurohara K, et al., Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28 |
All: |
4 reference(s) |
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