Bub3tm1Jvd
Targeted Allele Detail
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| Symbol: |
Bub3tm1Jvd |
| Name: |
BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen |
| MGI ID: |
MGI:3619247 |
| Synonyms: |
Bub3- |
| Gene: |
Bub3 Location: Chr7:131162081-131173625 bp, + strand Genetic Position: Chr7, 74.36 cM
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| Alliance: |
Bub3tm1Jvd page
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Reduced lifespan, cataract, lordokyphosis and cachexia in Bub3tm1Jvd/Bub3+ Rae1tm1Jvd/Rae1+ mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:81546
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The coding region was interrupted at amino acid 191 by homologous recombination. Exon 3 was replaced with a neomycin resistance gene in reverse orientation. Western blot detected the encoded protein in heterozygous mice at reduced levels.
(J:81546)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Bub3tm1Jvd
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Bub3 Mutation: |
23 strains or lines available
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| Original: |
J:81546 Babu JR, et al., Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003 Feb 3;160(3):341-53 |
| All: |
2 reference(s) |
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Analysis Tools
