Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tuba1aJna
Name:	tubulin, alpha 1A; jenna
MGI ID:	MGI:3617352
Synonyms:	Gena227
Gene:	Tuba1a  Location: Chr15:98847728-98851382 bp, - strand  Genetic Position: Chr15, 55.29 cM
Alliance:	Tuba1aJna page

Strain of Origin:	BALB/cAnN
Project Collection:	Harwell ENU Mutagenesis

Allele Type:    Chemically induced (ENU) Mutation:    Nucleotide substitutions   Mutation details: This phenotypic mutation was identified in an ENU mutagenesis screen and contains a mutation that causes an amino acid change from serine to glycine at residue 140. This mutation reduced GTP binding and native heterodimer formation. (J:117881) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tuba1a Mutation:	15 strains or lines available

Original:	J:117881 Keays DA, et al., Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell. 2007 Jan 12;128(1):45-57
All:	6 reference(s)