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Gene Expression Data
Assay Details
Assay
Reference: J:104492 Huang KM, et al., Xcat, a novel mouse model for Nance-Horan syndrome inhibits expression of the cytoplasmic-targeted Nhs1 isoform. Hum Mol Genet. 2006 Jan 15;15(2):319-27
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3615232
Gene symbol: Nhs
Gene name: NHS actin remodeling regulator
Antibody: anti-Nhs1
Detection system: Secondary antibody coupled to Alexa Fluor 568
Assay notes: After sectioning, slides were fixed with ice cold 1:1 acetone:methanol.
Results
Specimen 4B: postnatal newborn (more )
Note: Transverse section.
Structure Level Pattern Image Note
TS27: lens epithelium Moderate 4C , 4B
TS27: lens fiber Strong 4C , 4B
Specimen 4E: postnatal newborn; NhsXcat/Nhs+ (more )
Note: This mutation is an X linked dominant; it is possible this specimen was a homozygous female or a mutant male. Transverse section.
Structure Level Pattern Image Note
TS27: eye Trace 4F , 4E The trace staining seen in the mutant is in a pattern clearly distinct from the wild type staining pattern.
Specimen 4H: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: lens fiber Present 4H
Specimen 4I: postnatal newborn; NhsXcat/Nhs+ (more )
Note: This mutation is an X linked dominant; it is possible this specimen was a homozygous female or a mutant male.
Structure Level Pattern Image Note
TS27: lens fiber Absent 4I
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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