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C5ar2tm1Cge
Targeted Allele Detail
Summary
Symbol: C5ar2tm1Cge
Name: complement component 5a receptor 2; targeted mutation 1, Craig Gerard
MGI ID: MGI:3612426
Synonyms: C5L2-
Gene: C5ar2  Location: Chr7:15968512-15978079 bp, - strand  Genetic Position: Chr7, 8.77 cM
Alliance: C5ar2tm1Cge page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104092
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 1 kb of coding sequence was replaced with genes encoding green fluorescent protein and neomycin resistnace under the control of the pgk promoter. Transcript was not detected by RT-PCR of mutant bone marrow. (J:104092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any C5ar2 Mutation:  18 strains or lines available
References
Original:  J:104092 Gerard NP, et al., An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem. 2005 Dec 2;280(48):39677-80
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory