Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smc1atm1Mbk
Name:	structural maintenance of chromosomes 1A; targeted mutation 1, Michael B Kastan
MGI ID:	MGI:3612278
Synonyms:	Smc1S957AS966A
Gene:	Smc1a  Location: ChrX:150799386-150844969 bp, + strand  Genetic Position: ChrX, 68.46 cM
Alliance:	Smc1atm1Mbk page

Germline Transmission:	Earliest citation of germline transmission: J:104490
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted Mutation:    Nucleotide substitutions     Two serines were mutated to alanines at positions 957 and 966 in exon 19. (J:104490)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smc1a Mutation:	10 strains or lines available

Original:	J:104490 Kitagawa R, et al., Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004 Jun 15;18(12):1423-38
All:	3 reference(s)