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Gene Expression Data
Assay Details
Assay
Reference: J:88448 Kusumi K, et al., Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Mech Dev. 2001 Jan;100(1):141-4
Assay type: RNA in situ
MGI Accession ID: MGI:3611832
Gene symbol: Dll3
Gene name: delta like canonical Notch ligand 3
Probe: Dll3 cDNA2
Probe preparation: Antisense RNA
Assay notes: It is possible another probe (MGI:2446514) was used in this assay.
Results
Specimen 1D: embryonic day 10.75 (more )
Structure Level Pattern Image Note
TS17: midbrain Strong 1D There is a series of bilateral and longitudinal stripes detected in the mid/hindbrain territory.
TS17: rhombomere Strong Regionally restricted 1D There is strong expression in the rhombic lips. There is a series of bilateral and longitudinal stripes detected in the mid/hindbrain territory.
TS17: hindbrain roof plate Strong 1D
TS17: future spinal cord Present Regionally restricted 1D There is a wide dorsal band along the spinal cord.

Specimen Not shown: embryonic day 10.75 (more )
Structure Level Pattern Image Note
TS17: head mesenchyme Absent There is no expression in cranial neural crest or head mesodermal derivatives.

Specimen 2A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trigeminal preganglion Present 2A

Specimen 2B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trigeminal preganglion Present 2B

Specimen 2C: embryonic day 9.5 (more )
Note: This is a ventral view.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present 2C
TS15: rhombomere 2 Strong 2C
TS15: rhombomere 4 Strong 2C
TS15: rhombomere 5 Absent 2C
TS15: rhombomere 6 Absent 2C

Specimen 2D: embryonic day 9.5 (more )
Note: This is a lateral view.
Structure Level Pattern Image Note
TS15: future midbrain Present 2D
TS15: neural tube lateral wall Present 2D
TS15: rhombomere 2 Strong 2D
TS15: rhombomere 4 Strong 2D
TS15: rhombomere 5 Absent 2D
TS15: rhombomere 6 Absent 2D

Specimen 2E: embryonic day 9.75 (more )
Note: This specimen is from a series along the A-P axis of the embryo; it is the most rostral section.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2E Changes in expression reflect the temporal progression of spinal cord development. Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and domains of motor neuron differentiation.

Specimen 2F: embryonic day 9.75 (more )
Note: This specimen is from a series along the A-P axis of the embryo.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2F Changes in expression reflect the temporal progression of spinal cord development. Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and domains of motor neuron differentiation.

Specimen 2G: embryonic day 9.75 (more )
Note: This specimen is from a series along the A-P axis of the embryo.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2G Changes in expression reflect the temporal progression of spinal cord development. Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and domains of motor neuron differentiation.

Specimen 2H: embryonic day 9.75 (more )
Note: This specimen is from a series along the A-P axis of the embryo; it is the most caudal section.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2H Changes in expression reflect the temporal progression of spinal cord development. Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and domains of motor neuron differentiation.

Specimen 2I: embryonic day 9.75 (more )
Note: Lateral view of the embryo sectioned in 2E-H.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present 2I

Specimen 2J: embryonic day 10.25 (more )
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2J Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and ventrolateral domains of motor neuron differentiation.
TS15: neural tube floor plate Absent 2J

Specimen 2K: embryonic day 9.5-10.25 (more )
Note: The exact age of the specimen was not reported.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2K Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and ventrolateral domains of motor neuron differentiation.
TS15: neural tube floor plate Absent 2K

Specimen 2L: embryonic day 9.5-10.25 (more )
Note: The exact age of the specimen was not reported.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2L Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and ventrolateral domains of motor neuron differentiation.
TS15: neural tube floor plate Absent 2L

Specimen 2M: embryonic day 9.5-10.25 (more )
Note: The exact age of the specimen was not reported.
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present Regionally restricted 2M Expression coincides with the program of commissural neuron differentiation and is excluded from the ventricular zone and ventrolateral domains of motor neuron differentiation.
TS15: neural tube floor plate Absent 2M

Specimen 3A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: rhombomere 2 Present 3A
TS15: rhombomere 4 Present 3A
TS15: rhombomere 5 Weak Regionally restricted 3A There is weak expression in the ventral rhombomere.
TS15: rhombomere 6 Weak Regionally restricted 3A There is weak expression in the ventral rhombomere.

Specimen 3B: embryonic day 9.75 (more )
Structure Level Pattern Image Note
TS15: rhombomere 2 Present 3B
TS15: rhombomere 4 Present 3B
TS15: rhombomere 5 Present 3B
TS15: rhombomere 6 Present 3B

Specimen 3C: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: rhombomere 2 Present 3C
TS16: rhombomere 4 Present 3C
TS16: rhombomere 5 Present 3C
TS16: rhombomere 6 Present 3C

Specimen 3D: embryonic day 10.25 (more )
Structure Level Pattern Image Note
TS16: rhombomere 2 Present 3D
TS16: rhombomere 4 Present 3D
TS16: rhombomere 5 Present 3D
TS16: rhombomere 6 Present 3D

Specimen 3E: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 2 Present 3E
TS17: rhombomere 4 Present 3E
TS17: rhombomere 5 Present 3E
TS17: rhombomere 6 Present 3E

Specimen 3F: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: rhombomere 2 Present 3F
TS14: rhombomere 4 Present 3F

Specimen 3G: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: rhombomere 2 Present 3G Expression is present at the ventral midline, marking the developing motor neuron pools of the future Vth and VIIth nuclei.
TS15: rhombomere 4 Present 3G Expression is present at the ventral midline, marking the developing motor neuron pools of the future Vth and VIIth nuclei.
TS15: rhombomere 5 Weak 3G
TS15: rhombomere 6 Weak 3G

Specimen 3H: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: rhombomere 2 Present 3H Expression is present at the ventral midline, marking the developing motor neuron pools of the future Vth and VIIth nuclei.
TS16: rhombomere 4 Present 3H Expression is present at the ventral midline, marking the developing motor neuron pools of the future Vth and VIIth nuclei.
TS16: rhombomere 5 Present 3H
TS16: rhombomere 6 Present 3H

Specimen 3I: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 2 Present 3I Expression is upregulated at the rhombomere boundaries.
TS17: rhombomere 4 Present 3I Expression is upregulated at the rhombomere boundaries.
TS17: rhombomere 5 Present 3I Expression is upregulated at the rhombomere boundaries.
TS17: rhombomere 6 Present 3I Expression is upregulated at the rhombomere boundaries.

Specimen 3J: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: rhombomere 2 Present 3J Expression is upregulated at the rhombomere boundaries.
TS18: rhombomere 4 Present 3J Expression is upregulated at the rhombomere boundaries.
TS18: rhombomere 5 Present 3J Expression is upregulated at the rhombomere boundaries.
TS18: rhombomere 6 Present 3J Expression is upregulated at the rhombomere boundaries.

Specimen 4B Wt: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 4B Wt Expression is present in longitudinal columns that presumably reflect the differentiation of distinct subpopulations of neurons.

Specimen 4B pu: embryonic day 10.5; Dll3pu/Dll3pu (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 4B pu Expression is present in longitudinal columns that presumably reflect the differentiation of distinct subpopulations of neurons. There is no difference in expression between mutant and wild type.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory