Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xdhtm1Fink
Name:	xanthine dehydrogenase; targeted mutation 1, Toren Finkel
MGI ID:	MGI:3611749
Synonyms:	Xor-
Gene:	Xdh  Location: Chr17:74190890-74257191 bp, - strand  Genetic Position: Chr17, 45.25 cM
Alliance:	Xdhtm1Fink page

Germline Transmission:	Earliest citation of germline transmission: J:103558
Parent Cell Line:	GSI-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was used to replace portions of exon 3 and exon 4 and the entire intron 3 with a neomycin resistance cassette via homologous recombination. Transcript was not detected in mutant livers by RT-PCR. Protein activity in postnatal livers was not detected in a flurometric assay. (J:103558)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xdh Mutation:	100 strains or lines available

Original:	J:103558 Ohtsubo T, et al., Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. Circ Res. 2004 Nov 26;95(11):1118-24
All:	6 reference(s)