Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sphk2tm1Rlp
Name:	sphingosine kinase 2; targeted mutation 1, Richard L Proia
MGI ID:	MGI:3611080
Synonyms:	SK2-, Sphk2-
Gene:	Sphk2  Location: Chr7:45358891-45367426 bp, - strand  Genetic Position: Chr7, 29.45 cM
Alliance:	Sphk2tm1Rlp page

Germline Transmission:	Earliest citation of germline transmission: J:103755
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ-neo cassette replaced half of exon 4 through the end of exon 7 by homologous recombination. RT-PCR analysis of total RNA form adult tissues failed to detect transcript in mutants. (J:103755)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Sphk2 Mutation:	38 strains or lines available

Original:	J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
All:	57 reference(s)