Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Angptl3tm1Akos
Name:	angiopoietin-like 3; targeted mutation 1, Anja Koster
MGI ID:	MGI:3610614
Synonyms:	Angptl3-
Gene:	Angptl3  Location: Chr4:98919191-98926429 bp, + strand  Genetic Position: Chr4, 45.6 cM
Alliance:	Angptl3tm1Akos page

Germline Transmission:	Earliest citation of germline transmission: J:103363
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to remove 1.3 kb of sequence, including exon 1 containing the start codon. Northern blot failed to detect transcript in mutant liver tissue. (J:103363)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angptl3 Mutation:	35 strains or lines available

Original:	J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50
All:	1 reference(s)