Mrtfbtm1Eno
Targeted Allele Detail
|
|
| Symbol: |
Mrtfbtm1Eno |
| Name: |
myocardin related transcription factor B; targeted mutation 1, Eric N Olson |
| MGI ID: |
MGI:3608959 |
| Synonyms: |
MRTF-B- |
| Gene: |
Mrtfb Location: Chr16:13074345-13235393 bp, + strand Genetic Position: Chr16, 9.24 cM
|
| Alliance: |
Mrtfbtm1Eno page
|
|
Branchial arch artery abnormalities in Mrtfbtm1Eno/Mrtfbtm1Eno embryos
Show the 4 phenotype image(s) involving this allele.
|
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:102475
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
129
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: A targeting construct was designed to delete exon 8 by the introduction of a lacZ and neomycin resistance cassette. Deletion of exon 8 results in a truncated protein containing only the first 270 amino acids of the protein and lacking the SRF-binding, dimerization, and transcription activation domains. The mutated protein is functionally intert.
(J:102475)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Mrtfb Mutation: |
68 strains or lines available
|
|
| Original: |
J:102475 Oh J, et al., Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15122-7 |
| All: |
2 reference(s) |
|
Analysis Tools
