Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Gabra3tm1Dgen
Name:	gamma-aminobutyric acid type A receptor subunit alpha 3; targeted mutation 1, Deltagen
MGI ID:	MGI:3604586
Gene:	Gabra3  Location: ChrX:71476287-71700454 bp, - strand  Genetic Position: ChrX, 37.24 cM
Alliance:	Gabra3tm1Dgen page

Mutant Cell Line:	2626
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Disruption caused by insertion of vector   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the brainstem and olfactory bulb and lower levels in all other tissues analyzed. Beta-galactosidase expression from this allele is detectable in brain, dorsal horns and dorsal root ganglia of the spinal cord and lens of the eye. Expression was also detectable in aorta, a few cells of the heart and kidney, some blood vessels of the lung and liver and tunica albuginea of testis.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

51 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra3 Mutation:	6 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	1 reference(s)