Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Fzd1tm1Dgen
Name:	frizzled class receptor 1; targeted mutation 1, Deltagen
MGI ID:	MGI:3604554
Gene:	Fzd1  Location: Chr5:4803839-4808035 bp, - strand  Genetic Position: Chr5, 2.61 cM
Alliance:	Fzd1tm1Dgen page

Mutant Cell Line:	3016
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in lung, kidney, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, colon, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat and low levels in whole brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, liver, pancreas, spleen, thymus, lymph nodes, bone marrow, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum and testis. Beta-galactosidase expression from this allele is detectable in most organs examined. Most striking expression was detected in the central nervous system, muscularis of the urinary bladder and blood vessels. Staining was observed in different tissue and cell types, including cardiac muscle, epithelium, neurons, cartilage, adipose tissue and blood vessels.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

129 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd1 Mutation:	29 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	1 reference(s)