Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Htr7tm1Dgen
Name:	5-hydroxytryptamine (serotonin) receptor 7; targeted mutation 1, Deltagen
MGI ID:	MGI:3604477
Gene:	Htr7  Location: Chr19:35936134-36034907 bp, - strand  Genetic Position: Chr19, 30.3 cM
Alliance:	Htr7tm1Dgen page

Mutant Cell Line:	6034
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Disruption caused by insertion of vector   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in subcortical region, brainstem and spinal cord. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, cerebellum, olfactory bulb, eye, Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat. LacZ expression was detected in: brain, spinal cord, skeletal muscle, testis and prostate gland. LacZ expression was not detected in: sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, parathyroid gland, pituitary gland, adrenal glands, skin, mammary gland, ovary, uterus and cervix.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

45 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr7 Mutation:	32 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	1 reference(s)