Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dkk2tm1Dwu
Name:	dickkopf WNT signaling pathway inhibitor 2; targeted mutation 1, Dianqing Wu
MGI ID:	MGI:3590649
Synonyms:	Dkk2-
Gene:	Dkk2  Location: Chr3:131791053-131886065 bp, + strand  Genetic Position: Chr3, 61.32 cM, cytoband H2
Alliance:	Dkk2tm1Dwu page

Germline Transmission:	Earliest citation of germline transmission: J:100858
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced the four coding exons via homologous recombination. RT-PCR failed to detect transcript in mutant bone marrow stromal osteoblasts, and western blot confirmed absence of protein in mutants. (J:100858)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dkk2 Mutation:	22 strains or lines available

Original:	J:100858 Li X, et al., Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005 Sep;37(9):945-52
All:	10 reference(s)