Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Transgene Detail
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| Symbol: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell |
| Name: |
transgene insertion N8, John F Elliott |
| MGI ID: |
MGI:3590083 |
| Synonyms: |
DQ6 transgene, HLA-DQ6 transgene, Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell |
| Transgene: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell Location: unknown
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| Alliance: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell expresses
3 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CD4 (920) |
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| human |
HLA-DQA1 (3117) |
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| human |
HLA-DQB1 (3119) |
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Mutation details: The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained.
(J:113267)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:113267 Hayward SL, et al., CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol. 2006 Jun 15;176(12):7715-25 |
| All: |
3 reference(s) |
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Analysis Tools
