Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dgkitm1Mtop
Name:	diacylglycerol kinase, iota; targeted mutation 1, Matthew K Topham
MGI ID:	MGI:3584141
Synonyms:	Dgki-
Gene:	Dgki  Location: Chr6:36822957-37277119 bp, - strand  Genetic Position: Chr6, 15.6 cM
Alliance:	Dgkitm1Mtop page

Germline Transmission:	Earliest citation of germline transmission: J:99817
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of the catalytic domain encoded by exon 14 was replaced by a neomycin resistance gene in reverse orientation. RT-PCR confirmed that no full-length or truncated transcript was expressed in mutant liver tissue. (J:99817)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dgki Mutation:	38 strains or lines available

Original:	J:99817 Regier DS, et al., Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7595-600
All:	4 reference(s)