Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Spry2tm1Ayos
Name:	sprouty RTK signaling antagonist 2; targeted mutation 1, Akihiko Yoshimura
MGI ID:	MGI:3584128
Synonyms:	Sprouty2-
Gene:	Spry2  Location: Chr14:106129381-106134253 bp, - strand  Genetic Position: Chr14, 56.16 cM
Alliance:	Spry2tm1Ayos page

Germline Transmission:	Earliest citation of germline transmission: J:99827
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced most of exon 2. RT-PCR failed to detect transcript and protein was absent in Western blot of mutant MEFs. (J:99827)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry2 Mutation:	24 strains or lines available

Original:	J:99827 Taketomi T, et al., Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 2005 Jul;8(7):855-7
All:	5 reference(s)