Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Polgtm1Prol
Name:	polymerase (DNA directed), gamma; targeted mutation 1, Tomas A Prolla
MGI ID:	MGI:3583920
Synonyms:	mtDNA-mutator, PolgA, PolgAD257A, Polgm, Polgmut, Polgtm1Tprol
Gene:	Polg  Location: Chr7:79095979-79116110 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Alliance:	Polgtm1Prol page

Germline Transmission:	Earliest citation of germline transmission: J:99764
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: A targeting construct was designed to introduce an AC to CT two-base substitution in positions 1054 and 1055, resulting in a critical residue substitution in the conserved exonuclease domain (D257A). (J:99764)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:	57 strains or lines available

Original:	J:99764 Kujoth GC, et al., Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005 Jul 15;309(5733):481-4
All:	43 reference(s)