Gene Expression Data
Assay Details
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Assay
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Reference:
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J:91307
Korteweg N, et al., Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur J Neurosci. 2004 Jun;19(11):2944-52
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:3581518
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Gene symbol:
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Avp
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Gene name:
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arginine vasopressin
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Antibody:
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GP antiserum
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Detection system:
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Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
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Results
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Specimen
2A:
embryonic day 14.5
(more  )
Note: This is a coronal section.
Specimen
2A:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Note:
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This is a coronal section.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: hypothalamus |
Present |
Regionally restricted |
2A
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Expression is present in neurons in the ventrolateral hypothalamus, adjacent to the optic tract.
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Specimen
2B:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
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Stxbp1tm1Sud/Stxbp1tm1Sud
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Note:
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This is a coronal section.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: hypothalamus |
Present |
Regionally restricted |
2B
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Expression is present in neurons in the ventrolateral hypothalamus, adjacent to the optic tract.
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Specimen
2C:
embryonic day 14.5
(more )
Note: This is a coronal section.
Specimen
2C:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Note:
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This is a coronal section.
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Specimen
2D:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
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Stxbp1tm1Sud/Stxbp1tm1Sud
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Note:
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This is a coronal section.
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Specimen
3B:
embryonic day 14.5
(more )
Specimen
3B:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Specimen
3D:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
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Age:
|
embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: median eminence |
Present |
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3D
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Expression is present in fibers; there are fewer in the mutant compared to wild type.
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Specimen
3F:
embryonic day 14.5
(more )
Specimen
3F:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
|
Bouin's Fixative
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Embedding:
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Paraffin
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Specimen
3H:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
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Stxbp1tm1Sud/Stxbp1tm1Sud
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Age:
|
embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Bouin's Fixative
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Embedding:
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Paraffin
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Specimen
4A:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
4A:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
|
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: hypothalamus |
Present |
Regionally restricted |
4A
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Expression is present in the supraoptic nucleus.
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Specimen
4B:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
4B:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
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Sex:
|
Not Specified
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Type:
|
section
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|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: hypothalamus |
Present |
Regionally restricted |
4B
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Expression is present in the paraventricular nucleus.
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Specimen
4C:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
4C:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
|
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
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|
Note:
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This is a coronal section.
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Specimen
4D:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
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Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: hypothalamus |
Present |
Regionally restricted |
4D
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Expression is present in the supraoptic nucleus; it is less clustered in the mutant compared to wild type.
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Specimen
4E:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: hypothalamus |
Present |
Regionally restricted |
4E
|
Expression is present in the paraventricular nucleus; it is less clustered in the mutant compared to wild type.
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Specimen
4F:
(close )
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Genetic Background:
|
Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
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Specimen
5A:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
5A:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: median eminence |
Present |
|
5A
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Expression is present in dense fibers.
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Specimen
5B:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
5B:
(close )
|
Genetic Background:
|
Not Specified
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Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
Specimen
5C:
embryonic day 16.5
(more )
Note: This is a coronal section.
Specimen
5C:
(close )
|
Genetic Background:
|
Not Specified
|
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Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
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Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: neurohypophysis pars nervosa |
Strong |
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5C
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Expression is present in dense fibers on the periphery of the neural lobe; there is no staining in the center of the lobe.
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Specimen
5D:
(close )
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Genetic Background:
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Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: median eminence |
Present |
|
5D
|
Expression is present in fibers; they are less dense in the mutants compared to wild type.
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Specimen
5E:
(close )
|
Genetic Background:
|
Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: neurohypophysis infundibulum |
Present |
Regionally restricted |
5E
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Expression is present in fibers in the pituitary stalk; they are less dense in the mutants compared to wild type and restricted to the ventral portion of the stalk.
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Specimen
5F:
(close )
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Genetic Background:
|
Not Specified
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Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: neurohypophysis pars nervosa |
Present |
|
5F
|
Expression is present in fibers in the neural lobe; they are less dense in the mutants compared to wild type.
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Specimen
6A:
embryonic day 18.5
(more )
Note: This is a coronal section.
Specimen
6A:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: hypothalamus |
Present |
Regionally restricted |
6A
|
Expression is present in clustered neurons in the paraventricular and supraoptic nuclei, as well as in magnocellular neurons.
|
Specimen
6B:
embryonic day 18.5
(more )
Note: This is a coronal section.
Specimen
6B:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: hypothalamus |
Present |
Regionally restricted |
6B
|
Expression is present in clustered neurons in the paraventricular and supraoptic nuclei, as well as in magnocellular neurons.
|
Specimen
6C:
embryonic day 18.5
(more )
Note: This is a coronal section.
Specimen
6C:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
Specimen
6D:
(close )
|
Genetic Background:
|
Not Specified
|
|
Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: hypothalamus |
Present |
Single cells |
6G
,
6D
|
There are only a few expressing cells in the mutants.
|
Specimen
6E:
(close )
|
Genetic Background:
|
Not Specified
|
|
Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: hypothalamus |
Present |
Single cells |
6E
|
There are only a few expressing cells in the mutants.
|
Specimen
6F:
(close )
|
Genetic Background:
|
Not Specified
|
|
Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
Note:
|
This is a coronal section.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: median eminence |
Present |
Regionally restricted |
6F
|
There is scattered expression in the mutants.
|
Specimen
7B:
embryonic day 18.5
(more )
Specimen
7B:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
Specimen
7D:
embryonic day 18.5
(more )
Specimen
7D:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: neurohypophysis pars nervosa |
Present |
Regionally restricted |
7D
|
Expression is present in fibers in the periphery of the neural lobe.
|
Specimen
7G:
(close )
|
Genetic Background:
|
Not Specified
|
|
Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
Specimen
7I:
(close )
|
Genetic Background:
|
Not Specified
|
|
Mutant Allele(s):
|
Stxbp1tm1Sud/Stxbp1tm1Sud
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
Bouin's Fixative
|
|
Embedding:
|
Paraffin
|
|
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