Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mn1tm1Ecz
Name:	meningioma 1; targeted mutation 1, Ellen C Zwarthoff
MGI ID:	MGI:3580381
Synonyms:	Mn1-
Gene:	Mn1  Location: Chr5:111565228-111604899 bp, + strand  Genetic Position: Chr5, 53.86 cM
Alliance:	Mn1tm1Ecz page

Germline Transmission:	Earliest citation of germline transmission: J:98889
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a neomycin resistance gene into the first exon resulted in the generation of a truncated protein of 121 amino acids, missing less over 90% the protein including the transcription activating domain and the glutamine stretch. (J:98889)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mn1 Mutation:	37 strains or lines available

Original:	J:98889 Meester-Smoor MA, et al., Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. Mol Cell Biol. 2005 May;25(10):4229-36
All:	3 reference(s)