Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Slc9a4tm1Ges Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull MGI ID: MGI:3579458 Synonyms: NHE4- Gene: Slc9a4  Location: Chr1:40619241-40669885 bp, + strand  Genetic Position: Chr1, 19.51 cM Alliance: Slc9a4tm1Ges page

Abnormal gastric epithelium in 9 week old Slc9a4tm1Ges/Slc9a4tm1Ges mice Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:98566
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting construct was designed to insert a neomycin resistance into exon 2. Northern blot demonstrated a reduction in the size of the transcript in mutant stomach tissue. Sequence analysis showed that exon 2 and the neo gene had been excised and exon 1 was spliced to exon 3. (J:98566)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc9a4 Mutation:	39 strains or lines available

Original:	J:98566 Gawenis LR, et al., Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. J Biol Chem. 2005 Apr 1;280(13):12781-9
All:	2 reference(s)