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Ptprctm1Tyb
Targeted Allele Detail
Summary
Symbol: Ptprctm1Tyb
Name: protein tyrosine phosphatase receptor type C; targeted mutation 1, Victor L J Tybulewicz
MGI ID: MGI:3579087
Synonyms: Cd45-
Gene: Ptprc  Location: Chr1:137990599-138103446 bp, - strand  Genetic Position: Chr1, 60.73 cM
Alliance: Ptprctm1Tyb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57681
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 12, which encodes part of the extracellular domain and is common to all isoforms, was disrupted by the insertion of a neomycin resistance gene. Flow cytometry of splenocytes, lymphocytes, lymph node and bone marrow cells with an antibody recognizing all isoforms failed to detect protein on any cells. (J:57681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  188 strains or lines available
References
Original:  J:57681 Mee PJ, et al., Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur J Immunol. 1999 Sep;29(9):2923-33
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory