Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp1r17tm1Nkz
Name:	protein phosphatase 1, regulatory subunit 17; targeted mutation 1, Toru Nakazawa
MGI ID:	MGI:3577713
Gene:	Ppp1r17  Location: Chr6:55994482-56009674 bp, + strand  Genetic Position: Chr6, 27.65 cM, cytoband C1
Alliance:	Ppp1r17tm1Nkz page

Germline Transmission:	Earliest citation of germline transmission: J:97966
Parent Cell Line:	MS12 (ES Cell)
Strain of Origin:	C57BL/6NSlc

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A tau-AFAP-pgk-neo cassette replaced exon 2, which includes the sequence encodinge the initiating methionine. The PGK-neo was subsequently removed via cre-mediated recombination. Northern blot and RT-PCR confirmed lack of transcript in mutant mice. Immunoreactivity was found to be absent in analysis of retinae of mutant mice. (J:97966)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp1r17 Mutation:	13 strains or lines available

Original:	J:97966 Nakazawa T, et al., Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):58-68
All:	2 reference(s)