Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Chfrtm1Jc
Name:	checkpoint with forkhead and ring finger domains; targeted mutation 1, Junjie Chen
MGI ID:	MGI:3576266
Synonyms:	Chfr-
Gene:	Chfr  Location: Chr5:110283708-110319838 bp, + strand  Genetic Position: Chr5, 53.32 cM
Alliance:	Chfrtm1Jc page

Germline Transmission:	Earliest citation of germline transmission: J:97428
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the exon spanning nt 132-237 that encodes part of the FHA domain. Immunoblotting of mutant MEFs confirmed lack of protein. (J:97428)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Chfrtm1Jc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chfr Mutation:	36 strains or lines available

Original:	J:97428 Yu X, et al., Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr;37(4):401-6
All:	4 reference(s)