Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(tetO-EGFP/FADD)1Doi
Name:	transgene insertion 1, Christophe Benoist
MGI ID:	MGI:3574423
Transgene:	Tg(tetO-EGFP/FADD)1Doi  Location: unknown
Alliance:	Tg(tetO-EGFP/FADD)1Doi page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Dominant negative, Inducible, Inserted expressed sequence, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-EGFP/FADD)1Doi expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human FADD (8772) Fadd  (MGI:109324)   Mutation details: The transgene encodes a fusion protein consisting of a truncated, dominant-negative mutant Fas-associated death domain protein in which amino acids 1-79, constituting the death effector domain, have been replaced by the full-length enhanced green fluorescent protein. The coding sequence, preceded by a minimal CMV promoter and a rabbit beta-globin intron and followed by the beta-globin polyadenylation signal, resides downstream of seven copies of the tet operator (tetO). TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline. (J:94935, J:95005)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:95005 Vence L, et al., DN-FADD and Diabetes. Personal Communication. 1995;
All:	2 reference(s)