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Spry1tm1Jdli
Targeted Allele Detail
Summary
Symbol: Spry1tm1Jdli
Name: sprouty RTK signaling antagonist 1; targeted mutation 1, Jonathan D Licht
MGI ID: MGI:3574403
Synonyms: Spryflox
Gene: Spry1  Location: Chr3:37694096-37698747 bp, + strand  Genetic Position: Chr3, 18.46 cM
Alliance: Spry1tm1Jdli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96485
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    All three exons, including exon 3 that contains the ORF, was flanked with loxP sites. (J:96485)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 70 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Spry1tm1Jdli
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry1 Mutation:  15 strains or lines available
References
Original:  J:96485 Basson MA, et al., Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005 Feb;8(2):229-39
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory