Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Del(2Hoxd8,Hoxd9-Hoxd13)1Cx
Name:	deletion, Chr 2, Cox 1; deletion, Chr 2, Gregory A Cox 1
MGI ID:	MGI:3574364
Synonyms:	Del1Cx, Irn, Ironside
Gene:	Del(2Hoxd8,Hoxd9-Hoxd13)1Cx  Location: unknown  Genetic Position: Chr2, Syntenic

Strain of Origin:

NZW/LacJ

Allele Type:    Spontaneous Mutations:    Intergenic deletion, Intragenic deletion   Del(2Hoxd8,Hoxd9-Hoxd13)1Cx involves 10 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all   Mutation details: A large noncontiguous deletion of two neighboring regions (approximately 8 kb and 43 kb) left an approximately 2 kb region containing exon 1 of the Hoxd8 gene in the locus between the deleted regions. The end result is a functional deletion of Hox8d, d9, d10, d11, d12 and d13. The flanking genes, Evx2 and Hoxd4, remained intact. (J:103924) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(2Hoxd8,Hoxd9-Hoxd13)1Cx Mutation:	1 strain or line available

Original:	J:103924 Tarchini B, et al., HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
All:	2 reference(s)